Polyneuropathy as Paraneoplastic Syndrome in a Patient with Metastatic Diffuse Large B-Cell Lymphoma
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Case Report

Polyneuropathy as Paraneoplastic Syndrome in a Patient with Metastatic Diffuse Large B-Cell Lymphoma

Turk J Dermatol 2021;15(3):77-79 DOI: 10.4103/tjd.tjd_38_21
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Abstract

Paraneoplastic syndromes are multisystemic diseases that are seen in association with solid organ tumors and lymphomas. Immune-mediated polyneuropathy, encephalopathy, cerebellar degeneration, and Guillain–Barre syndrome have all been described as paraneoplastic neurologic disorders. Clinical symptoms may appear before the diagnosis of associated malignancy creating diagnostic confusion. Tumor-derived peptides, hormones, and mediators are shown to be associated with paraneoplastic syndromes. Herein, we present an unusual case of stage 4 diffuse large B-cell lymphoma with cutaneous metastatic nodules presenting initially as paraneoplastic polyneuropathy.

Keywords: B-cell lymphoma, paraneoplastic, polyneuropathy