Abstract
Giant cell tumors of the skin are known to be extremely rare tumors, grossly, and histologically similar to that of giant cell tumors of bone. A 16-year-old girl presented with an asymptomatic swelling over the right cheek, which had progressed over 5 months duration without any antecedent history of local trauma and infection. Grossly, the specimen was brown-colored without any pigmentation, fleshy, and consisted of a skin-covered globular mass measuring 1.5 × 1.0 × 0.5 cm. On histopathologic examination, sections examined show a well-circumscribed lesion involving the dermis and revealed biphasic population of round to spindle-shaped mononuclear cells with intimately admixed osteoclast-like giant cells. On immunohistochemistry, osteoclast-like giant cells and mononuclear cells showed strong cytoplasmic granular positivity for CD68 and final diagnosis of giant cell tumor was given.
Keywords: CD68, giant cell tumor, osteoclast-like giant cells
