Abstract
Objective
Adenosine deaminase (ADA), which is accepted as a non-specific marker of T cell activation in psoriasis, has been shown to have an important role in determining activity of disease and efficacy of treatments. This is the first study investigating the levels of ADA in lesional skins of patients with psoriasis.
Methods:
Thirty-four patients; 26 with chronic plaque type and eight with guttate psoriasis were enrolled in this study. Patients were treated with PUVA or narrowband UVB. Contol group consisted of 25 patients who had an amputation of any extremity because of trauma. In this study, ADA activities were measured in plasma and tissue samples of patients and control group. Psoriasis Area and Severity Index (PASI) scores of patients were determined.
Results:
Plasma and tissue ADA levels of patients with psoriasis were higher than control group (p<0.05). Also in same patients, after PUVA and narrowband UVB treatments, plasma and tissue ADA levels were significantly lower than before treatments (p<0.05). However, no significiant correlation was observed between levels of ADA and PASI scores. (p>0.05).
Conclusion
These results support the immunological mechanisms showing activation of T cell acts in the pathogenesis of psoriasis and also this study suggests that the levels of plasma and tissue ADA are reliable laboratory parameters in follow-up of the disease.
Keywords: Psoriasis, plasma adenosine deaminase, tissue adenosine deaminase, PUVA, narrowband UVB, cellular immunity\r\n
