A Case with Cowden Syndrome
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Case Report

A Case with Cowden Syndrome

Turk J Dermatol 2015;9(2):92-95 DOI: 10.4274/tdd.2009
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Abstract

Cowden syndrome is an autosomal dominant rare inherited disorder characterized by multiple hamartomas in variety of tissues from all three embryonic layers. Mucocutaneous lesions like facial trichilemmomas, acral keratoses, papillomatous papules, also macrocephaly and malignancies including breast, tyhroid and endometrial carcinoma are hallmark of the disease. Here we report a 47-year-old male patient with mucucutaneous lesions, gastrointestinal polyposis and macrocephaly diagnosed as Cowden syndrome.

Keywords: Cowden syndrome, intestinal polyposis, macrocephaly, papilloma, PTEN mutation, hereditary cancer syndromes