ABSTRACT

Hailey-Hailey disease is an autosomal dominantly inherited chronic bullous dermatosis that tends to remain localized to flexural areas. The typical onset of the disease is through papulovesicles or flaccid bullae on an erythematous background. Lesions are often painful and itchy and sometimes cause a burning sensation. Although there is no effective treatment for the disease, topical and systemic corticosteroids and antibiotics are often used in the treatment. Hailey-Hailey disease creates a predisposition to infections due to the deterioration of skin barrier function. Underlying secondary infections should be investigated, particularly in cases with treatment failure. In this article we present a case of Hailey-Hailey disease who did not obtain benefits with conventional treatment modalities and was showing dramatic improvement due to treatment with acyclovir.