E-ISSN: 1308-5255 ISSN: 1307-7635
Brain–Skin Connection The Contemporary Perspective through Neuroendocrinology
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Review
VOLUME: 14 ISSUE: 2
P: 29-34
June 2020

Brain–Skin Connection The Contemporary Perspective through Neuroendocrinology

Turk J Dermatol 2020;14(2):29-34
DOI: 10.4103/TJD.TJD_44_19
Ayşenur Botsali 1
Osman Köse 2
1. Department of Dermatology, Faculty of Health Sciences, Gulhane School of Medicine
2. Prof. Dr. Osman Kose Private Office, Dermatologist, Ankara, Turkey
No information available.
No information available
Received Date: 14.12.2019
Accepted Date: 22.02.2020
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ABSTRACT

This review summarizes the novel and precious data on the direct effects of ancient neuroendocrinologic molecules on the skin and hair and additionally the active production of these hormones by resident skin cells. The data are extracted from PubMed using the keywords neuroendocrinology, hormones, skin, hair follicle, pituitary, hypothalamus, thyroid, and prolactin. The most important neuroendocrinologic axis is composed of corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol (CRH–ACTH–cortisol) and is related to stress. The CRH–ACTH–cortisol axis is demonstrated to be fully functional in the skin. This review furthermore points out to a possible neuroendocrinologic mechanism likely to explain the association between psychological stress and skin and hair diseases.