E-ISSN: 1308-5255 ISSN: 1307-7635
Comparison of Serum Dehydroepiandrosterone Sulfate, Testosterone, and Dihydrotestosterone Levels in Males with Various Degrees of Acne Vulgaris Severity
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Original Article
VOLUME: 13 ISSUE: 2
P: 60-64
June 2019

Comparison of Serum Dehydroepiandrosterone Sulfate, Testosterone, and Dihydrotestosterone Levels in Males with Various Degrees of Acne Vulgaris Severity

Turk J Dermatol 2019;13(2):60-64
DOI: 10.4103/TJD.TJD_12_19
Arif Widiatmoko
Tantari Sugiman
Taufiq Hidayat
Krisna Ariaputra
Firmina Kus Setianingrum
Dhini Indah Nugriaty
1. Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia
No information available.
No information available
Received Date: 02.07.2019
Accepted Date: 02.07.2019
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ABSTRACT

Objective:

This study compared the levels of dehydroepiandrosterone (DHEA) sulfate, testosterone, and dihydrotestosterone (DHT) in the serum of men with various degrees of severity grading of acne vulgaris.

Methods:

We conducted a cross-sectional analytic observational study and used the Combined Acne Severity Classification. Serum DHEA sulfate (DHEAS), testosterone, and DHT levels were measured by enzyme-linked immunosorbent assay. We recruited 63 males with acne vulgaris.

Results:

For mild, moderate, or severe acne, the mean serum level of DHEAS was 90.92, 153.54, and 166.67 ng/ml (P = 0.000); testosterone was 6.66, 8.11, and 8.97 ng/ml (P = 0.445); and DHT was 87.33, 111.72, and 124.71 (P = 0.01), respectively. Post hoc analysis showed significant differences for DHEAS and DHT serum levels. There were significant differences for DHEAS and DHT serum levels.

Conclusion:

There was no significant difference in serum testosterone levels between groups, although there was an increase in concentration by acne vulgaris severity.

Keywords:
Acne vulgaris, degree of severity, dehydroepiandrosterone sulfate, dihydrotestosterone, testosterone