E-ISSN: 1308-5255 ISSN: 1307-7635
Correlation between Psoriasis and ZIP2 and ZIP3 Zinc Transporters
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Original Article
VOLUME: 14 ISSUE: 3
P: 61-64
September 2020

Correlation between Psoriasis and ZIP2 and ZIP3 Zinc Transporters

Turk J Dermatol 2020;14(3):61-64
DOI: 10.4103/TJD.TJD_29_20
Sevilay Kılıç 1
Hilal Müserref Şehitoğlu 2
1. Department of Dermatology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey
2. Department of Biochemistry, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey
No information available.
No information available
Received Date: 08.04.2020
Accepted Date: 25.05.2020
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ABSTRACT

Aims:

Psoriasis is a chronic, inflammatory, hyperproliferative skin disease with etiopathogenesis not fully understood. The zinc transporter ZIP2 is associated with keratinocyte differentiation, whereas ZIP3 is associated with T-lymphocyte maturation. In our study, we aimed to show the correlation between psoriasis and ZIP2 and ZIP3 zinc transporters in psoriasis patients.

Subjects and Methods:

The patient group in the study included 60 patients aged with psoriasis vulgaris and a control group of 60 healthy adults. The levels of ZIP2 (SLC39A2) and ZIP3 (SLC39A3) zinc transporters were determined with the ELISA method. Results were compared with control group values and statistically assessed.

Results:

When the ZIP2 and ZIP3 levels are compared in controls and psoriasis patients, the levels were observed to significantly increase compared to controls (P < 0.05). When compared to the control group, the results appeared to be statistically significant (P < 0.05).

Conclusions:

With etiopathogenesis not fully known, there may be an important relationship between psoriasis development and ZIP2 (SLC39A2) and ZIP3 (SLC39A3) zinc transporters in psoriasis vulgaris patients. This situation may be an important result for understanding how the disease develops and in creating new approaches in terms of treatment for this disease without full cure available.