Evaluation of oxidative stress levels as biomarkers in vitiligo patients

Turk J Dermatol 2023;17(4):132-135

1. Department of Bioengineering, Faculty of Engineering and Natural Sciences, Bursa Technical University, Bursa, Turkey

2. Medical Faculty, Bezmialem Vakıf University, İstanbul, Turkey

3. Department of Medical Biochemistry, Hamidiye Faculty of Medicine, University of Health Sciences, Uskudar, Istanbul, Turkey

4. Liv Hospital, Dermatology Clinic, Ulus, Istanbul, Turkey

5. Department of Dermatology, Bezmialem Vakif University, Fatih, Istanbul, Turkey

6. Department of Medical Biochemistry, Haydarpasa Numune Health Application and Research Center, University of Health Sciences, Uskudar, Istanbul, Turkey

No information available.

No information available

Received Date: 17.09.2023

Accepted Date: 19.12.2023

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ABSTRACT

Objective:

Vitiligo is a skin disease that causes the loss of melanocyte cells, which produce pigment in the skin. There is evidence that oxidative stress plays an important role in vitiligo disease of unknown pathogenesis. Evidence suggests that there is increased oxidative stress in melanocytes in patients with vitiligo. The aim of this study is to investigate oxidative stress markers in patients with vitiligo.

Materials and Methods:

Blood samples were taken from 23 vitiligo patients and 23 healthy control groups without any disease in Bezmialem Vakıf University Hospital Dermatology and Venereal Diseases Outpatient Clinic. Total antioxidant levels (TAS) and total oxidant levels (TOS) were measured photometrically method with blood samples. The oxidative stress index (OSI) was calculated as the TOS to TAS level ratio.

Results:

When the results of the vitiligo patient group were compared with the control group, TOS and OSI were found to be significantly higher than the control group (P < 0.05). No statistically significant result was found in TAS.

Conclusions:

Our results show that oxidative stress plays a role in the pathogenesis of vitiligo.