ABSTRACT

A rare type of liken pilanopilaris, Graham-Little-Piccardi-Lassueur syndrome (GLPLS), is characterized by cicatricial alopecia of the scalp, follicular hyperkeratosis of trunk and extremities and non-cicatricial alopecia of axilla and pubis. A forty year-old woman admitted with hair loss and palpabl wheals on her body. On her dermatologic examination alopecic plaques with irregular border and atrophic appearance and milimetric papules around follicules on fronto-parietal part of scalp were detected. Also there were purple like-brown milimetric papules around follicules on both extensor part of distal arm, axilla, upper and lower back with alopecia on hairy areas. Additionally milimetric purplish papules on flexor area of wrists were accompanied to other signs. In histopathological investigation of the biopsy from scalp and back lesions were demonstrated orthokeratosis on superficial layer of epidermis, vacuolar degeneration and exocytosis on basal layer of epidermis and basal layer of follicular epithelium, perifollicular infiltration of mix type inflammatory cells, a few pigmentation deposited macrophages. The patient was diagnosed as GLPLS based on these symptoms and signs. Early diagnosis and treatment of this chronic, progressive characterized, rare type of lichen planopilaris is important. Treatments modalities could stop progression and provide partial remission, although they can’t success complete improvement.