E-ISSN: 1308-5255 ISSN: 1307-7635
Paraneoplastic Pemphigus and Nipple Hyperkeratosis Triggered with Castleman Disease
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Case Report
VOLUME: 13 ISSUE: 1
P: 49-51
March 2019

Paraneoplastic Pemphigus and Nipple Hyperkeratosis Triggered with Castleman Disease

Turk J Dermatol 2019;13(1):49-51
DOI: 10.4274/tdd.galenos.2014.2456
Banu Çağlar Seçil Saral
Bengü Nisa Akay
Nihal Kundakçı
1. Ankara Üniversitesi Tıp Fakültesi, İbni Sina Hastanesi, Dermatoloji Kiniği, Ankara, Türkiye
No information available.
No information available
Received Date: 29.09.2014
Accepted Date: 15.12.2014
Publish Date: 22.03.2019
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ABSTRACT

Castleman disease is a rarely seen lymphoproliferative disease. Paraneoplastic pemphigus can lead the way in the diagnosis of Castleman disease as these two diseases can co-occur. Nipple hyperkeratosis is associated with malignancies as a part of cutaneous lymphoma and malignant acanthosis nigricans. Castleman disease and nipple hyperkeratosis have never been previously reported in the literature. Herein, we present a case of Castleman disease diagnosed with further investigations that occurs paraneoplastic pemphigus emergent with severe stomatitis and vesiculobullous lesions in the body and nipple hyperkeratosis in the nipples.

References

1
Bonekamp D, Horton KM, Hruban RH, et al. Castleman disease: the great mimic. Radiographics 2011;31:1793-807.
2
Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 1972;29:670-83.
3
Moon WK, Im JG, Kim JS, et al. Mediastinal Castleman disease: CT findings. J Comput Assist Tomogr 1994;18:43-6.
4
Zimmermann J, Bahmer F, Rose C, et al. Clinical and immunopathological spectrum of paraneoplastic pemphigus. J Dtsch Dermatol Ges 2010;8:598-606.
5
Anhalt GJ1, Kim SC, Stanley JR, et al. Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med 1990;323:1729-35.
6
Robinson ND, Hashimoto T, Amagai M, et al. The new pemphigus variants. J Am Acad Dermatol 1999;40:649-71; quiz 672-3.
7
Frew JW, Murrell DF. Paraneoplastic pemphigus (paraneoplastic autoimmune multiorgan syndrome): clinical presentations and pathogenesis. Dermatol Clin 2011;29:419-25, viii.
8
Vezzoli P, Berti E, Marzano AV. Rationale and efficacy for the use of rituximab in paraneoplastic pemphigus. Expert Rev Clin Immunol 2008;4:351-63.
9
Mehanna A, Malak JA, Kibbi AG. Hyperkeratosis of the nipple and areola: report of 3 cases. Arch Dermatol 2001;137:1327-8.
10
Toros P, Onder M, Gürer MA. Bilateral nipple hyperkeratosis treated successfully with topical isotretinoin. Australas J Dermatol 1999;40:220-2.
11
Banuchi SR, Cohen L, Lorincz AL, et al. Acanthosis nigricans following diethylstilbestrol therapy. Occurrence in patients with childhood muscular dystrophy. Arch Dermatol 1974;109:545-6.
12
Schwartz RA. Hyperkeratosis of nipple and areola. Arch Dermatol 1978;114:1844-5.
13
Mold DE, Jegasothy BV. Estrogen-induced hyperkeratosis of the nipple. Cutis 1980;26:95-6.