ABSTRACT

Leptin is a cytokine like peptide hormone produced by adipocytes. Its primary sources are is visceral and subcutaneous adipose tissues. It is produced in various tissues such as placenta, gastric epithelium, skeletal muscle, hypophysis as well as mammary gland and released into the plasma. It regulates food intake and body weight. It also plays an important roles in reproduction, endocrine and immune responses. The role of leptin is being investigated in the pathogenesis of many diseases. Several studies have demonstrated investigated the effects of leptin in dermatological diseases. In this review, the effects of leptin on dermatological diseases were are agreed to be presented through examining the current literature.