E-ISSN: 1308-5255 ISSN: 1307-7635
Retrospective Analysis of Cases With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis A Case Series of 20 Patients
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Original Article
VOLUME: 16 ISSUE: 3
P: 80-86
September 2022

Retrospective Analysis of Cases With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis A Case Series of 20 Patients

Turk J Dermatol 2022;16(3):80-86
DOI: 10.4103/tjd.tjd_13_22
Kifayat Mammadlı 1
Asli Bilgiç 1
Hatice Deniz İlhan 2
Oguz Dursun 3
Murat Yılmaz 4
Erkan Alpsoy 1
1. Akdeniz University, Department of Dermatology and Venereology, Antalya, Turkey
2. Akdeniz University, Department of Ophthalmology, Antalya, Turkey
3. Akdeniz University, Department of Pediatrics, Intensive Care Subunit, Antalya, Turkey
4. Akdeniz University, Department of Anesthesia and Reanimation, Antalya, Turkey
No information available.
No information available
Received Date: 12.01.2022
Accepted Date: 14.04.2022
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ABSTRACT

Background:

Stevens-Johnson syndrome (SJS)/ toxic epidermal necrolysis (TEN) are rare, acute, severe cutaneous hypersensitivity reactions usually triggered by medications. They are classified by the extent of the detached skin surface area.

Objective:

We aimed to retrospectively evaluate the sociodemographic, clinical, therapeutic, and prognostic characteristics of SJS/TEN cases diagnosed between January 2015 and December 2020 in our centre.

Materials and Methods:

All the data regarding patient characteristics were obtained retrospectively. The SCORe of Toxic Epidermal Necrolysis (SCORTEN) was used to predict disease severity and mortality rates.

Results:

Out of 20 patients (14 females, 6 males), eight (40%) were evaluated as TEN, three (15%) as SJS/ TEN overlap, and nine (45%) as SJS. The mean age was 39.2 ± 27.92 years. A higher frequency of systemic antibiotic use was found in cases of SJS/TEN overlap or TEN compared to SJS cases during patients’ follow-up after the diagnosis (P = 0.006). The most common responsible drug was allopurinol (25%). While the estimated mortality in patients with SCORTEN values of 4 and 5 was 58.3% and 90.0%, the mortality observed in our cohort was 50% and 100%, respectively. In terms of complications, ocular problems were the most common ones. Ophthalmic sequelae were observed in 15 patients during the follow-up period, the most common belonging to the cornea.

Conclusion:

In conclusion, early diagnosis, immediate discontinuation of suspected drugs, and good clinical care are among the most crucial treatment steps in the treatment of SJS/TEN. In addition, multidisciplinary management of the disease is vital in preventing the development of long-term sequelae in survivors.