E-ISSN: 1308-5255 ISSN: 1307-7635
The Effect of Coenzyme Q10 on Serum Glutathione Peroxidase Levels and Severity of Acne Vulgaris
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Original Article
VOLUME: 14 ISSUE: 3
P: 71-75
September 2020

The Effect of Coenzyme Q10 on Serum Glutathione Peroxidase Levels and Severity of Acne Vulgaris

Turk J Dermatol 2020;14(3):71-75
DOI: 10.4103/TJD.TJD_51_20
Maria Leleury
Diah Adriani
Retno Indar Widayati
Asih Budiastuti
1. Department of Dermatovenereology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
No information available.
No information available
Received Date: 15.05.2020
Accepted Date: 16.07.2020
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ABSTRACT

Objective:

The objective of the study was to study the effect of coenzyme Q10 (CoQ10) supplementation on serum glutathione peroxidase (GSH-Px) levels and the severity of acne vulgaris (AV).

Methods:

A double-blind randomized controlled trial was carried out on 36 patients with AV classified according to severity. These patients were randomly divided into two groups (treatment group = 18 patients treated with tretinoin 0.025% cream and once-daily supplementation with a CoQ10 100 mg tablet; placebo group = 18 patients treated with tretinoin 0.025% cream and a once-daily placebo tablet). Blood samples were taken from a vein and examined by enzyme-linked immunosorbent assay. The study period was 8 weeks. Response to treatment was determined based on serum GSH-Px level and AV severity. The study used a pre- and post-test design for the two groups. The data were processed with SPSS for Windows version 25.

Results:

Administration of CoQ10 to AV significantly improved the severity of AV after 8 weeks compared to a placebo (P = 0.008). Serum GSH-Px levels after treatment with CoQ10 increase higher in the study than control group, but the statistical test result showed not significant in the study group (P = 0.3) and also control group (P = 0.07).

Conclusion:

CoQ10 supplementation may increase serum GSH-Px levels and improve the severity of AV, but there was no relationship between serum GSH-Px levels and the severity of AV.