Thiol/Disulfide Homeostasis in Patients with Telogen Effluvium is Oxidative Stress Important in the Pathogenesis of Telogen Effluvium?

Turk J Dermatol 2019;13(4):131-134

DOI: 10.4103/TJD.TJD_26_19

1. Departments of Medical Microbiology

2. Medical Biochemistry and Urology

3. Hitit University Erol Olcok Education and Research Hospital

4. Departments of Dermatology and Plastic and Reconstructive Surgery

5. Hitit University Faculty of Medicine, Çorum

6. Department of Medical Biochemistry, Ankara City Hospital, Ankara, Turkey

No information available.

No information available

Received Date: 02.10.2019

Accepted Date: 10.11.2019

PDF

Cite

Request

ABSTRACT

Objective:

The aim of this study was to assess the correlation between telogen effluvium (TE) with the new oxidative stress (OS) indicator of thiol/disulfide balance and to research the role of OS in the pathogenesis of TE.

Methods:

Our study included 101 patients with TE diagnosis and 39 healthy individuals. Serum thiol/disulfide was measured with a new automated spectrometric method developed by Erel and Neselioglu, and results were compared statistically.

Results:

Among the six thiol/disulfide parameters, there were statistically significant differences for native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol studied in the patient and control groups (P = 0.042, 0.044, <0.001, 0.013, 0.026, and < 0.001, respectively).

Conclusions:

Based on the results of this study, it can be said that OS is closely associated with TE pathogenesis. There is a need for new studies that will show the possible effects of OS on TE pathogenesis and research different OS markers in addition to thiol/disulfide parameters.