ABSTRACT

Dowling-Degos disease (DDD) is a rare genodermatosis characterized by reticular hyperpigmented macules that mainly involve the flexural areas. Although it frequently occurs an autosomal dominant trait, sporadic cases have also been reported. It has been thought to occur due to mutations in the keratin 5 gene.

Dowling-Degos disease is sometimes accompanied by other cutaneous abnormalities as perioral atrophic scars, hyperkeratotic folliculer lesions, comedo-like papules as well. Herein, a 44-yr-old woman with typical clinical features and histopathologic findings is presented.