ABSTRACT

Papuloerythroderma of Ofuji is characterized by a pruritic eruption of widespread, red, flat papules that leads to spare skin folds. The disease occurs primarily in elderly men and is often associated with lymphadenopathy, peripheral blood eosinophilia, lymphopenia and elevated immunoglobulin E levels.

Association with T and B cell lymphomas, visceral carcinomas, AIDS, atopic dermatitis, psoriasis and hypersensitivity to drugs have been reported. Topical and systemic corticosteroids, psoralen-UVA, etretinate-PUVA, acitretin-PUVA, UVB, cyclosporin, interferon α and azathioprine have been used in the treatment of this rare disease. In this manuscript, we described two patients with papuloerythroderma of Ofuji.(Turk J Dermatol 2011; 5: 13-7)